Research Fellow in KSHV-Host Cell Interactions at University of Leeds

Are you an early career researcher looking for your first challenge? Do you have a background in Molecular virology and virus-host cell interactions Do you want to further your career in one of the UK’s leading research intensive Universities?

Project Title: Kaposi’s sarcoma-associated herpesvirus manipulation of nuclear sub-domains

The Whitehouse research group is seeking a highly motivated Research Fellow to investigate how the human tumor virus, Kaposi’s sarcoma-associated herpesvirus (KSHV), manipulates ribosome biogenesis pathways and nuclear condensates to enhance its own replication. The project will use a range of molecular and cell biology approaches to highlight a novel KSHV-mediated mechanism to regulate viral gene expression. Moreover, this project aims to identify a novel target for antiviral intervention for this important human tumor virus.

The successful candidate will become part of a multi-member laboratory team investigating the molecular mechanisms of viral infection and the essential role of virus-host cell events. These are fundamentally important to ultimately develop new effective antiviral agents that target viral proteins or host factors.

For this role, you should have a PhD (or close to completion) in molecular virology or a closely allied discipline. You should also have experience in growth, analysis and manipulation of Kaposi’s sarcoma-associated herpesvirus, as well as in virus-mediated manipulation of ribosome biogenesis pathways and nuclear condensates.

Experience in a wide range of RNA-based techniques, qRT-PCR, protein production, mammalian cell culture, immunoblotting, and lentivirus-shRNA depletion approaches in B cells is also essential.

To explore the post further or for any queries you may have, please contact:

Professor Ade WhitehouseProfessor of Molecular Virology

Tel: +44 (0)113 343 7096 Email: a.whitehouse@leeds.ac.uk

Location: Leeds – Main Campus

Grade:

Grade 7

Salary:

£pa

Working Time:

100% – we are open to discussing flexible working arrangements

Post Type:

Full time

Contract Type:

Fixed Term (36 months – available from 1st January 2023 due to external funding)

Release Date:

Tuesday 13 September 2022

Closing Date:

Monday 19 September 2022

Reference:

FBSMB1236

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